VTWO vs XBI: Holdings Overlap
VTWOVanguard Russell 2000 Index Fund
Vanguard · 1952 holdings · $17.4B · as of 2026-05-31
XBIState Street® SPDR® S&P® Biotech ETF
State Street (SPDR) · 149 holdings · $10.0B · as of 2026-08-06
Holdings snapshots are 67 days apart (VTWO: 2026-05-31, XBI: 2026-08-06). Weights and index membership change between snapshots, so the true current overlap is typically higher than shown. For funds tracking the same index, the gap can be 5–15 points.
How similar are VTWO and XBI?
Vanguard Russell 2000 Index Fund (VTWO, by Vanguard) holds 1952 positions; State Street® SPDR® S&P® Biotech ETF (XBI, by State Street (SPDR)) holds 149. They have 113 holdings in common, and by portfolio weight the two funds are 7.4% identical. In practical terms the pair is lightly overlapping, with most of each portfolio distinct.
- Overlap by Weight
- 7.4%Sum of the smaller weight of each shared holding
- Shared Holdings
- 113VTWO holds 1952 · XBI holds 149
- Weight in Shared Holdings
- VTWO 7%·XBI 72%Share of each fund's weight in stocks both funds own
Based on each fund's latest official holdings. How is this calculated?
What makes each fund different
Only in VTWO
1839 of 1952 positions (92.3% of the fund) are not held by XBI. Showing the top 30 by weight.
Only in XBI
36 of 149 positions (27.8% of the fund) are not held by VTWO. Showing the top 30 by weight.
Sector Breakdown
| Sector | VTWO | XBI |
|---|---|---|
| Health Care | 15.5% | 95.5% |
| Industrials | 19.4% | 0.0% |
| Information Technology | 17.8% | 0.0% |
| Financials | 14.3% | 0.0% |
| Consumer Discretionary | 7.3% | 0.0% |
| Other Sectors | 20.8% | 0.0% |
| Unclassified | 4.8% | 4.6% |
Share of each fund's portfolio weight by GICS-style sector, compiled from issuer fund data and our own classification of the holdings, not the issuers' published sector charts. “Unclassified” is weight we could not classify (5% of VTWO, 5% of XBI).
Performance
| Fund | 1M | YTD | 1Y | 3Y (ann.) | 5Y (ann.) | 10Y (ann.) | Yield |
|---|---|---|---|---|---|---|---|
| VTWO | +1.8% | +23.1% | +38.8% | +17.3% | +7.7% | +11.0% | 1.07% |
| XBI | -4.0% | +29.2% | +85.3% | +26.3% | +4.5% | +9.5% | 0.36% |
Total returns including dividends, from adjusted daily closes as of 2026-08-07. 3Y/5Y/10Y are annualized. Yield is trailing-12-month distributions over the last close. Past performance does not predict future results.
Project the growth of $10,000 in VTWO vs XBI →
Shared Holdings(113)
The top 10 shared positions account for 32% of the overlap, led by ARWR, BBIO and CYTK.
 ARWRArrowhead Pharmaceuticals Inc COM | 0.31% | 1.17% | 0.31% |
|---|---|---|---|
 BBIOBridgebio Pharma Inc COM | 0.31% | 1.19% | 0.31% |
 CYTKCytokinetics Incorporated | 0.29% | 1.17% | 0.29% |
 PRAXPraxis Precision Medicines Inc COM NEW | 0.26% | 1.49% | 0.26% |
 MDGLMadrigal Pharmaceuticals Inc COM | 0.25% | 1.05% | 0.25% |
 KRYSKrystal Biotech Inc COM | 0.22% | 1.00% | 0.22% |
 ALKSAlkermes PLC COM USD0.01 | 0.20% | 1.07% | 0.20% |
 PCVXVaxcyte Inc COM | 0.19% | 1.25% | 0.19% |
 PTCTPTC Therapeutics, Inc. COM | 0.17% | 0.93% | 0.17% |
 PTGXProtagonist Therapeutics Inc COM | 0.17% | 1.34% | 0.17% |
 TGTXTG Therapeutics Inc COM | 0.16% | 1.03% | 0.16% |
 SYRESpyre Therapeutics Inc COM NEW | 0.16% | 1.33% | 0.16% |
 1CGCRISPR Therapeutics AG COM CHF0.03 | 0.15% | 1.01% | 0.15% |
 COGTCogent Biosciences Inc. COM | 0.15% | 1.29% | 0.15% |
 RYTMRhythm Pharmaceuticals Inc COM | 0.14% | 1.26% | 0.14% |
 KYMRKymera Therapeutics Inc COM | 0.14% | 1.31% | 0.14% |
 CELCCelcuity Inc. COM | 0.14% | 1.02% | 0.14% |
 SRRKScholar Rock Holding Corp. COM | 0.13% | 1.15% | 0.13% |
 MIRMMirum Pharmaceuticals Inc. COM | 0.13% | 0.97% | 0.13% |
 TWSTTwist Bioscience Corporation COM | 0.12% | 1.56% | 0.12% |
 TVTXTravere Therapeutics Inc COM | 0.11% | 1.29% | 0.11% |
 CGONCG Oncology Inc. COM | 0.11% | 1.32% | 0.11% |
 APGEApogee Therapeutics Inc. COM | 0.11% | 1.57% | 0.11% |
 VCYTVeracyte Inc COM | 0.11% | 0.67% | 0.11% |
 DNTHDianthus Therapeutics Inc COM | 0.10% | 1.39% | 0.10% |
Frequently Asked Questions
How much do VTWO and XBI overlap?
VTWO and XBI overlap by 7.4% of portfolio weight. They share 113 holdings (VTWO holds 1952 positions and XBI holds 149), based on each fund's latest SEC-reported holdings.
Is it redundant to own both VTWO and XBI?
The two portfolios are 7.4% identical by weight. Owning both is not redundant. Most of each portfolio is distinct, so the funds can serve different roles.
What are the biggest shared holdings of VTWO and XBI?
The largest positions held by both funds are ARWR, BBIO, CYTK, PRAX and MDGL. Together the top 10 shared positions account for 32% of the total overlap.
What does VTWO own that XBI doesn't?
1839 positions (92.3% of VTWO) are unique to VTWO, led by BE, CRDO and STRL. In the other direction, 36 positions (27.8% of XBI) are unique to XBI.