XBIState Street® SPDR® S&P® Biotech ETF
Sector & Thematic ETF · State Street (SPDR)
Holdings as of Aug 6, 2026
XBI is a Sector & Thematic ETF from State Street (SPDR) holding 149 positions as of Aug 6, 2026, with $10.0B in assets and a 0.35% net expense ratio. Its largest positions are APGE (1.6%), TWST (1.6%) and PRAX (1.5%); the top 10 holdings account for 14.2% of the portfolio. It yields 0.36% on a trailing-12-month basis.
- Issuer
- State Street (SPDR)
- Holdings
- 149
- Net Assets
- $10.0BETF assets as of 2026-08-10
- Expense Ratio
- 0.35%per latest SEC prospectus filing
- TTM Yield
- 0.36%trailing 12-month distributions
Performance
- 1M
- -4.0%
- YTD
- +29.2%
- 1Y
- +85.3%
- 3Y (ann.)
- +26.3%
- 5Y (ann.)
- +4.5%
- 10Y (ann.)
- +9.5%
A $10,000 investment 10 years ago would be worth $24,873 today at the 10Y annualized rate. This is a backward-looking illustration, not a forecast. Project its future growth →
Total returns including dividends as of 2026-08-07. 3Y/5Y/10Y annualized. Past performance does not predict future results.
Sector Breakdown
| Health Care | 95.5% |
|---|---|
| Other Sectors | 0.0% |
| Unclassified | 4.6% |
We could not classify 5% of portfolio weight. It is shown separately as “Unclassified”, not lumped into a sector.
Top 25 Holdings
| # | Holding | Weight |
|---|---|---|
| 1 |  APGEApogee Therapeutics Inc. COM | 1.57% |
| 2 |  TWSTTwist Bioscience Corporation COM | 1.56% |
| 3 |  PRAXPraxis Precision Medicines Inc COM NEW | 1.49% |
| 4 |  ORKAOruka Therapeutics Inc COM | 1.49% |
| 5 |  INSMInsmed Inc COM PAR $.01 | 1.39% |
| 6 |  DNTHDianthus Therapeutics Inc COM | 1.39% |
| 7 |  PTGXProtagonist Therapeutics Inc COM | 1.34% |
| 8 |  SYRESpyre Therapeutics Inc COM NEW | 1.33% |
| 9 |  RVMDRevolution Medicines Inc COM | 1.33% |
| 10 |  ERASErasca Inc COM | 1.32% |
| 11 |  CGONCG Oncology Inc. COM | 1.32% |
| 12 |  KYMRKymera Therapeutics Inc COM | 1.31% |
| 13 |  TVTXTravere Therapeutics Inc COM | 1.29% |
| 14 |  COGTCogent Biosciences Inc. COM | 1.29% |
| 15 |  RYTMRhythm Pharmaceuticals Inc COM | 1.26% |
| 16 |  PCVXVaxcyte Inc COM | 1.25% |
| 17 |  REGNRegeneron Pharmaceuticals, Inc. COM | 1.24% |
| 18 |  RLAYRelay Therapeutics Inc COM | 1.21% |
| 19 |  ROIVRoivant Sciences Ltd SHS | 1.19% |
| 20 |  BBIOBridgebio Pharma Inc COM | 1.19% |
| 21 |  NTRANatera Inc. COM | 1.18% |
| 22 |  HALOHalozyme Therapeutics Inc COM | 1.18% |
| 23 |  ARWRArrowhead Pharmaceuticals Inc COM | 1.17% |
| 24 |  CYTKCytokinetics Incorporated | 1.17% |
| 25 |  VKTXViking Therapeutics Inc. COM | 1.16% |
Showing the top 25 of 149 holdings. See the full XBI holdings list →
XBI alternatives
The closest Sector & Thematic ETFs to XBI by portfolio overlap — the share of weight both funds hold in the same securities.
| Fund | Overlap | Expense | Assets | |
|---|---|---|---|---|
 IBBiShares Biotechnology ETF | 39% | 0.44%pricier | $9.3B | Compare → |
| 13% | 0.08%cheaper | $3.3B | Compare → | |
 VHTVanguard Health Care Index Fund | 13% | 0.09%cheaper | $18.3B | Compare → |
 IYHiShares U.S. Healthcare ETF | 11% | 0.38%pricier | $3.7B | Compare → |
 ARKGARK Genomic Revolution ETF | 9% | 0.75%pricier | $1.6B | Compare → |
 RSPHInvesco S&P 500 Equal Weight Health Care ETF | 9% | 0.4%pricier | $776M | Compare → |
 XLVState Street® Health Care Select Sector SPDR® ETF | 7% | 0.08%cheaper | $41.9B | Compare → |
 ARKKARK Innovation ETF | 7% | 0.75%pricier | $6.0B | Compare → |
Frequently Asked Questions
What is XBI's expense ratio?
XBI has a net expense ratio of 0.35%, per its latest SEC prospectus filing. That works out to about $35 a year on a $10,000 investment.
How many holdings does XBI have?
XBI held 149 positions as of Aug 6, 2026, per its latest official holdings data.
What are XBI's top 10 holdings?
XBI's largest positions are APGE (1.6%), TWST (1.6%), PRAX (1.5%), ORKA (1.5%), INSM (1.4%), DNTH (1.4%), PTGX (1.3%), SYRE (1.3%), RVMD (1.3%), ERAS (1.3%). Together they account for 14.2% of the portfolio.
What is XBI's dividend yield?
XBI yields 0.36% based on its trailing 12-month distributions, as of Aug 7, 2026.
How big is XBI?
XBI has $10.0B in assets as of Aug 10, 2026.
What are good alternatives to XBI?
By portfolio overlap, the closest Sector & Thematic ETFs to XBI are IBB (39% overlap), FHLC (13% overlap), VHT (13% overlap). Overlap measures the share of portfolio weight both funds hold in the same securities.