Which ETFs hold Spyre Therapeutics Inc COM NEW?
SYRE is held by 17 of the 504 ETFs we cover. The heaviest allocation is XBI at 1.3%; among the largest funds, VTI holds 0.0% and ITOT 0.0%. The median weight across all funds holding it is 0.1%. Spyre Therapeutics Inc COM NEW is classified Health Care.
- Covered ETFs Holding It
- 17
- Heaviest Allocation
- 1.33%in XBI
- Median Weight
- 0.06%across funds that hold it
- Sector
- Health Care
Funds Holding SYRE(17)
| ETF | |||||||
|---|---|---|---|---|---|---|---|
| XBIState Street® SPDR® S&P® Biotech ETF | 1.33% | 0.35% | $10.0B | 0.36% | +29.2% | +85.3% | +4.5% |
| IBBiShares Biotechnology ETF | 0.30% | 0.44% | $9.3B | 0.21% | +17.3% | +51.0% | +3.1% |
| VTWOVanguard Russell 2000 Index Fund | 0.16% | 0.06% | $17.4B | 1.07% | +23.1% | +38.8% | +7.7% |
| IWOiShares Russell 2000 Growth ETF | 0.16% | 0.24% | $14.8B | 0.42% | +21.0% | +34.7% | +5.9% |
| IWMiShares Russell 2000 ETF | 0.12% | 0.19% | $82.2B | 0.88% | +23.0% | +38.6% | +7.5% |
| SCHASchwab U.S. Small-Cap ETF | 0.12% | 0.04% | $23.3B | 1.02% | +22.8% | +36.7% | +7.9% |
| IWNiShares Russell 2000 Value ETF | 0.08% | 0.24% | $14.7B | 1.41% | +25.3% | +42.6% | +9.0% |
| FHLCFidelity MSCI Health Care Index ETF | 0.06% | 0.08% | $3.3B | 1.26% | +9.3% | +33.0% | +5.3% |
| VHTVanguard Health Care Index Fund | 0.06% | 0.09% | $18.3B | 1.51% | +9.2% | +32.8% | +5.4% |
| VXFVanguard Extended Market Index Fund | 0.05% | 0.05% | $32.2B | 0.99% | +18.9% | +26.9% | +6.9% |
| ONEQFidelity Nasdaq Composite Index ETF | 0.02% | 0.21% | $10.8B | 0.51% | +15.4% | +26.6% | +13.6% |
| VTHRVanguard Russell 3000 Index Fund | 0.01% | 0.06% | $4.8B | 0.99% | +14.5% | +24.0% | +12.4% |
| SCHBSchwab U.S. Broad Market ETF | 0.01% | 0.03% | $44.7B | 1.00% | +14.6% | +24.0% | +12.4% |
| ITOTiShares Core S&P Total U.S. Stock Market ETF | 0.01% | 0.03% | $97.6B | 0.97% | +14.6% | +24.1% | +12.3% |
| IWViShares Russell 3000 ETF | 0.01% | 0.20% | $20.4B | 0.85% | +14.3% | +23.8% | +12.2% |
| VTIVanguard Total Stock Market Index Fund | 0.01% | 0.03% | $696.4B | 1.02% | +14.6% | +24.2% | +12.3% |
| AVUSAvantis U.S. Equity ETF | 0.00% | 0.15% | $13.9B | 0.90% | +17.9% | +28.8% | +13.1% |
Expense = net expense ratio from the fund's latest SEC prospectus filing. YTD/1Y/5Y are trailing total returns including dividends (5Y annualized, as of 2026-08-07). Past performance does not predict future results. Sort by any column.
Frequently Asked Questions
Which ETF has the most SYRE exposure?
XBI has the heaviest SYRE allocation of the ETFs we cover, at 1.33% of its portfolio, based on the fund's latest SEC-reported holdings.
How many ETFs hold SYRE?
17 of the 504 ETFs we cover hold Spyre Therapeutics Inc COM NEW (SYRE). The median weight across those funds is 0.06%.
What is the cheapest ETF that holds SYRE?
SCHB has the lowest expense ratio among covered ETFs holding SYRE, at 0.03% per year.
What is the largest ETF that holds SYRE?
VTI (Vanguard Total Stock Market Index Fund) is the largest covered ETF holding SYRE, with $696.4B in assets and a 0.01% position.
Keep Exploring
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