Which ETFs hold Vertex Pharmaceuticals Incorporated COM?
VRTX is held by 80 of the 504 ETFs we cover. The heaviest allocation is IBB at 7.4%; among the largest funds, VOO holds 0.2% and IVV 0.2%. The median weight across all funds holding it is 0.2%. Vertex Pharmaceuticals Incorporated COM is classified Health Care.
- Covered ETFs Holding It
- 80
- Heaviest Allocation
- 7.44%in IBB
- Median Weight
- 0.21%across funds that hold it
- Sector
- Health Care
VRTX Share Performance
- 1M
- -5.0%
- YTD
- +9.4%
- 1Y
- +32.1%
- 3Y (ann.)
- +12.8%
- 5Y (ann.)
- +19.8%
- 10Y (ann.)
- +17.1%
A $10,000 investment 10 years ago would be worth $48,439 today at the 10Y annualized rate. This is a backward-looking illustration, not a forecast.
Total returns including dividends as of 2026-08-07. 3Y/5Y/10Y annualized. Past performance does not predict future results.
Funds Holding VRTX(80)
| ETF | |||||||
|---|---|---|---|---|---|---|---|
| IBBiShares Biotechnology ETF | 7.44% | 0.44% | $9.3B | 0.21% | +17.3% | +51.0% | +3.1% |
| XLVState Street® Health Care Select Sector SPDR® ETF | 2.07% | 0.08% | $41.9B | 1.53% | +7.9% | +30.7% | +6.2% |
| QQEWFirst Trust Nasdaq-100 Select Equal Weight ETF | 2.01% | 0.55% | $1.8B | 0.20% | +14.0% | +19.6% | +7.7% |
| IYHiShares U.S. Healthcare ETF | 1.99% | 0.38% | $3.7B | 1.14% | +8.1% | +30.4% | +5.3% |
| VHTVanguard Health Care Index Fund | 1.80% | 0.09% | $18.3B | 1.51% | +9.2% | +32.8% | +5.4% |
| FHLCFidelity MSCI Health Care Index ETF | 1.75% | 0.08% | $3.3B | 1.26% | +9.3% | +33.0% | +5.3% |
| CGUSCapital Group Core Equity ETF | 1.58% | 0.33% | $11.6B | 0.80% | +15.5% | +23.5% | — |
| CGGRCapital Group Growth ETF | 1.56% | 0.39% | $23.9B | 0.15% | +5.7% | +12.8% | — |
| RSPHInvesco S&P 500 Equal Weight Health Care ETF | 1.54% | 0.40% | $776M | 0.65% | +12.0% | +28.4% | +3.5% |
| IXJiShares Global Healthcare ETF | 1.50% | 0.40% | $4.1B | 1.41% | +5.9% | +25.5% | +4.8% |
| USMViShares MSCI USA Min Vol Factor ETF | 1.36% | 0.15% | $24.1B | 1.44% | +7.6% | +10.3% | +7.4% |
| CGBLCapital Group Core Balanced ETF | 1.25% | 0.33% | $7.5B | 1.83% | +9.5% | +16.6% | — |
| JEPIJPMorgan Equity Premium Income ETF | 1.24% | 0.35% | $45.8B | 7.95% | +5.5% | +11.6% | +7.5% |
| CGGOCapital Group Global Growth Equity ETF | 1.14% | 0.47% | $11.5B | 0.98% | +17.3% | +26.5% | — |
| XBIState Street® SPDR® S&P® Biotech ETF | 1.07% | 0.35% | $10.0B | 0.36% | +29.2% | +85.3% | +4.5% |
| CGDVCapital Group Dividend Value ETF | 0.80% | 0.33% | $37.4B | 1.14% | +18.2% | +28.6% | — |
| JEPQJPMorgan Nasdaq Equity Premium Income ETF | 0.67% | 0.35% | $39.9B | 10.92% | +10.1% | +21.5% | — |
| MGKVanguard Mega Cap Growth Index Fund | 0.65% | 0.07% | $33.7B | 0.32% | +10.2% | +19.4% | +14.0% |
| GPIQGoldman Sachs Nasdaq-100 Premium Income ETF | 0.65% | 0.29% | $5.4B | 9.88% | +16.2% | +26.4% | — |
| QQQInvesco QQQ Trust, Series 1 | 0.64% | 0.18% | $479.2B | 0.42% | +18.0% | +27.6% | +15.2% |
| QQQINEOS Nasdaq-100(R) High Income ETF | 0.63% | 0.68% | $13.9B | 13.81% | +11.3% | +20.0% | — |
| XTiShares Future Exponential Technologies ETF | 0.55% | 0.46% | $3.9B | 6.87% | +19.3% | +36.3% | +7.2% |
| QYLDGlobal X NASDAQ 100 Covered Call ETF | 0.55% | 0.60% | $8.2B | 11.64% | +10.1% | +21.5% | +8.2% |
| QQQMInvesco NASDAQ 100 ETF | 0.50% | 0.15% | $97.1B | 0.44% | +18.0% | +27.7% | +15.2% |
| ACWViShares MSCI Global Min Vol Factor ETF | 0.49% | 0.20% | $3.4B | 1.87% | +7.6% | +9.5% | +6.1% |
Expense = net expense ratio from the fund's latest SEC prospectus filing. YTD/1Y/5Y are trailing total returns including dividends (5Y annualized, as of 2026-08-07). Past performance does not predict future results. Sort by any column.
Frequently Asked Questions
Which ETF has the most VRTX exposure?
IBB has the heaviest VRTX allocation of the ETFs we cover, at 7.44% of its portfolio, based on the fund's latest SEC-reported holdings.
How many ETFs hold VRTX?
80 of the 504 ETFs we cover hold Vertex Pharmaceuticals Incorporated COM (VRTX). The median weight across those funds is 0.21%.
What is the cheapest ETF that holds VRTX?
BKLC has the lowest expense ratio among covered ETFs holding VRTX, at 0.00% per year.
What is the largest ETF that holds VRTX?
VOO (Vanguard 500 Index Fund) is the largest covered ETF holding VRTX, with $1.03T in assets and a 0.20% position.
Keep Exploring
Look up another stock or compare two of these ETFs to see how much they overlap beyond VRTX.